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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

The compound does not directly affect sex hormones, making it different from some other metabolic interventions

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Your body will start to adjust to the presence of a healthy level of B12 in the bloodstream